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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation

Fig. 4

Paxillin knockout attenuates the SPC-induced abnormal contraction of thoracic aorta. a, Representative contraction traces are shown for thoracic aorta from control and paxillin SMKO mice after stimulation with SPC at the different concentrations (1, 3, 10, and 30 µM). b, The SPC-induced contraction (mN) at the concentration of 3 µM and 10 µM from control (n = 10) and paxillin SMKO mice (n = 11). *p<0.05. c, Ratio of 3 µM and 10 µM SPC-induced contraction compared to 80 mM K+ depolarization-induced contraction in control (n= 9) and paxillin SMKO mice (n= 9). *p<0.05. Cont: control mice; PXN KO: paxillin SMKO mice

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Cell Communication and Signaling

ISSN: 1478-811X