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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation

Fig. 1

Paxillin knockdown inhibits the SPC-induced contraction in human CASMCs. a, Western blot showing paxillin expression in control shRNA or paxillin shRNA lentiviral particles infected human CASMCs in the absence and presence of SPC. b, Statistical analysis of paxillin expression in control shRNA and paxillin shRNA lentiviral particles infected human CASMCs (n = 4, **p < 0.01). c, Representative live cell imaging of cellular contraction at various time points following SPC stimulation (30 µM) in control shRNA and paxillin shRNA lentiviral particles infected human CASMCs. Scale bar = 100 µm. d, Statistical analysis of the cell area of control shRNA and paxillin shRNA lentiviral particles infected human CASMCs after SPC stimulation (30 µM) for 30 min. Three independent experiments were performed, and 100 cells were measured for the cell area using ImageJ. **p < 0.01; ns, no significant

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Cell Communication and Signaling

ISSN: 1478-811X