Table 2 Overview of m1A and its role in cancer mechanisms

LUAD

Writer ALKBH3

cGMP PKG mTOR Signaling, tRF-leu-CAG

cell apoptosis and tumor metabolism, cell cycle progression and proliferation

[47,48,49,50]

Breast cancer

ALKBH3 TRMT6

CSF-1 miR-191-5p

Invasion, proliferation and migration

[57, 58]

Colorectal-cancer

ALKBH1 Writer

SMAD7, MFAP2-CLK3

metastasis and prognosis, development, AJCC stage

[68,69,70]

Pancreatic-cancer

ALKBH1, ALKBH3, TRMT61B, Writer YTHDC1, YTHDF2

mTOR

and ErbB, EMT, TGF –β and mTOR C1 signaling

poor survival, proliferation, invasion and migration

[75,76,77]

Hepatocellular-carcinoma

TRMT6/TRMT61A, TRMT10C, YTHDF1

Hedgehog PPAR Signaling, PI3K/Akt signaling pathway

CSCs self-renewal and tumorigenesis, process of proliferation and apoptosis resistance

[68, 80,81,82]

Glioma-

ABCC3, ALKBH1, ALKBH3, TRMT61B, TRMT6, TRMT10C, TRMT61A

–

Proliferation and resistance

[88,89,90,91,92]

Bladder-cancer-

TRMT6/TRMT61A, ALKBH3

tRF-3- UPR, NOX-ROS signaling

Tumorigenesis, tumor angiogenesis and invasiveness

[97, 98]