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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: T-type voltage-gated channels, Na+/Ca2+-exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration

Fig. 8

Enzymatic signatures for rd1 photoreceptor degeneration and Spearman analysis. A Comparison of enzymatic markers across different experimental treatments. Normalized cell numbers positive for TUNEL (magenta), calpain activity (calpain, blue), activated calpain-2 (yellow), PARP activity (PARP, green), PAR (black), activated calpain-1 (cyan), and sirtuin (Sirt) activity (white). B Spearman analysis of enzymatic markers in photoreceptors (calpain activity, calpain-1, calpain-2, PARP activity, PAR, Sirtuin). The asterisks in circles show statistical significance, numbers in squares present the R. C Radar plot for Spearman analysis revealing the correlation between different enzymatic markers and the TUNEL assay. Note that while cell death (TUNEL) was strongly associated with general calpain activity, calpain-2 activation, PARP activity, and PAR, it was negatively correlated with calpain-1 activation and Sirtuin activity

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Cell Communication and Signaling

ISSN: 1478-811X