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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: T-type voltage-gated channels, Na+/Ca2+-exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration

Fig. 6

Differential correlation of calpain-1 and calpain-2 to photoreceptor cell death. A Spearman analysis comparing the numbers of activated calpain-1 and calpain-2 in the outer nuclear layer (ONL) of untreated rd1 retina and rd1 retina treated with the calpain-2 inhibitor NA-184. B Spearman analysis between the numbers of activated calpain-1 and dying, TUNEL positive cells in untreated or NA-184 treated rd1 ONL. C Spearman analysis between the ratio of calpain-2/calpain-1 and TUNEL positive cells in untreated or NA-184 treated rd1 ONL. D Alluvial diagram showing the relationship between activated calpain-2 and calpain-1, as well as TUNEL positive cells in rd1 ONL after treatment with BAPTA-AM, L-cis, CM4620, SN-6, D-cis, TTA-AS, DS5565, and NA-184

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Cell Communication and Signaling

ISSN: 1478-811X