Fig. 1

Whole tissue RNA-seq analysis highlights Ca²⁺-signalling-related changes in rd1 retina. A Heatmap for post-natal day 13 RNA-Seq data comparing the expression of Ca²⁺-related differentially expressed genes (DEGs) between rd1 and wild-type (wt) retina. In this group of genes, 32 were down- and 57 were up-regulated in rd1 retina. Color-coding indicates the logFC values (positive values in red, negative values in blue). B Gene set enrichment analysis (GSEA) showing upregulation of four Ca²⁺-related gene ontology (GO) pathways in rd1 retina (false discovery rate, FDR < 0.05). C Circle plot showing 10 different Ca²⁺-related GO terms (including biological processes (BPs) and molecular functions (MFs)) enriched in DEGs in the rd1 situation (p < 0.05). Color-coding of circles indicates the logFC values (positive values in red, negative values in blue); numbers in trapezoids indicate differentially expressed genes (red: upregulated; blue: downregulated); inner circle shows z-scores (increasing scores in red, decreasing scores in blue)