Fig. 2
From: Targeting the macrophage immunocheckpoint: a novel insight into solid tumor immunotherapy
TAMs affect tumor progression through a variety of cytokines and signaling pathways (TAMs can secrete growth factors and chemicals that promote angiogenesis, promoting tumor growth and proliferation. This can include inhibiting T cell activity, hindering immune cell infiltration, and weakening anti-tumor immune responses. Then, it can promote inflammatory response, increase cytokine secretion, and thus affect the microenvironment around tumors)