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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: TGFβ1-induced hedgehog signaling suppresses the immune response of brain microvascular endothelial cells elicited by meningitic Escherichia coli

Fig. 6

Schematic representation of the TGFβ1 or SAG immunosuppression effects on BMECs through upregulating miR-155 and negative regulating KRAS as well as downstream ERK1/2 signaling. The exogenous TGFβ1 or SAG triggered the HH signaling in E. coli-infected BMECs and upregulated intracellular miR-155. Further, the promoted miR-155 suppressed the ERK1/2 activation by negatively regulating KRAS, thus decreasing IL-6, MIP-2, and E-selectin expression

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Cell Communication and Signaling

ISSN: 1478-811X