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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Synergism of non-thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells

Fig. 3

NTP + RSL3 treatment induces excessive mitochondrial ROS generation and ferroptosis. A Effect of NAC (5 mM) on cell viability treated with NTP + RSL3. B H2O2 level in PAM detected at 1 h after NTP treatment. C Effect of CAT (1000 U/ml) treatment on cell viability (24 h) treated with NTP + RSL3. D H2O2 level in the plasma-treated medium. E H2O2 level in medium containing RSL3 (0.1 μM) after NTP treatment. F Cell viability (24 h) after H2O2 + RSL3 treatment. G The lipid peroxidation level after H2O2 + RSL3 treatment. H Quantification of G. I The mitochondrial ROS level after NTP + RSL3 treatment. J Quantification of I. K Effect of Mitotempo (200 μM) or NAC (5 mM) on cell viability treated with NTP + RSL3

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Cell Communication and Signaling

ISSN: 1478-811X