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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Synergism of non-thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells

Fig. 2

NTP + RSL3 treatment induces ferroptosis in NSCLC cells. A Effect of various inhibitors, Fer-1 (20 μM), Z-VAD-FMK (20 μM), Nec-1 s (20 μM) or CQ (100 μM) on cell viability after NTP + RSL3 treatment. B Typical fluorescent images and quantification of cellular lipid peroxidation at 24 h after treatment, N + R means NTP + RSL3, N + R + F means NTP + RSL3 + Fer-1. Scale bar, 50 μm. C Flow cytometry analysis of cellular lipid peroxidation. D Mitochondrial morphology captured by transmission electron microscopy. Scale bar, 1 μm (up) and 500 nm (down)

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Cell Communication and Signaling

ISSN: 1478-811X