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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback

Fig. 3

The SMYD3-mediated H3K4me3 modification level in primary human nasal epithelial cells influences the differentiation of cocultured naïve CD4 + T cells. A-B FACS results showing the percentage of Th2 cells in cocultures of primary human nasal epithelial cells pretreated with IL-4 in the presence or absence of BCI-121 for 72 h. The quantitative data are shown in (B) (n = 6 donors). C ELISA of IL-4, IL-5, IL-13 and IFN-γ secretion by cocultured naïve CD4 + T cells in the control group, IL-4 group and IL-4 stimulation + BCI-121 treatment group. Statistical significance (B-C), one-way ANOVA;***p < 0.001;**p < 0.01; ∗ p < 0.05

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Cell Communication and Signaling

ISSN: 1478-811X