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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback

Fig. 2

IL-4 stimulation induces robust SMYD3-mediated H3K4me3 modification in primary human nasal epithelial cells, and treatment with an SMYD3 inhibitor reduces this effect. A Quantitative RT‒PCR analysis results showing increased transcript levels of SMYD3 in human nasal epithelial cells from controls (untreated and treated with various cytokines (IL-4, IL-5 and IL-13)) (n = 3). Statistical significance, one-way ANOVA;*** p < 0.001. B Western blot analysis of H3K4me3 levels in human nasal epithelial cells treated with IL-13 or IL-4. C Immunoblot analysis of SMYD3 and H3K4me3 levels in primary human nasal epithelial cells stimulated with IL-4 and IL-4 + BCI-121 (50 μM) cultured in the ALI system (n = 3). I: IL-4 stimulation; C: control; B: IL-4 stimulation + BCI-121 treatment

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Cell Communication and Signaling

ISSN: 1478-811X