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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback

Fig. 1

Elevated levels of SMYD3-mediated H3K4me3 in the Th2-CRSwNP group but decreased levels in the non-Th2 CRSwNP group compared with the control group. A-B Histone H3 modification assay (A) and immunoblot analysis (B) of H3K4me3 in the three groups (control, Th2 CRSwNP and non-Th2 CRSwNP). H3 was used as a loading control for Western blotting. (n = 3/group). Statistical significance, one-way ANOVA;***p < 0.001;**p < 0.01. T: Th2 nasal polyps; C: control; N: non-Th2 nasal polyps. C and D Single-cell analysis of the distribution of specific H3K4me3-related enzymes (KMT2A, KMT2B, KMT2C, KMT2D, KDM4A, KDM5B, SETD1A, SETD1B and SMYD3) in various types of cells and in subgroups of epithelial cells. E Immunoblot analysis of SMYD3 expression in the three groups described in (B). GAPDH was used as a loading control for Western blotting..T: Th2 nasal polyps; C: control; N: non-Th2 nasal polyps (n = 3/group)

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Cell Communication and Signaling

ISSN: 1478-811X