Ferroptosis: a promising candidate for exosome-mediated regulation in different diseases

Liu, Limin; Ye, Yulin; Lin, Rui; Liu, Tianyu; Wang, Sinan; Feng, Zelin; Wang, Xiaoli; Cao, Hailong; Chen, Xin; Miao, Junming; Liu, Yifei; Jiang, Kui; Han, Zhibo; Li, Zongjin; Cao, Xiaocang

doi:10.1186/s12964-023-01369-w

Cell Communication and Signaling

Table 2 Mechanism of exosomes against ferroptosis in different diseases

From: Ferroptosis: a promising candidate for exosome-mediated regulation in different diseases

System	Disease types	Exosomes sources	Molecular mediators	Target	Biological effects	References
Digestive system	Acute liver injury	MSC	CD44/OTUB1	SLC7A11/system Xc-	Inhibit ferroptosis of hepatocyte and alleviate acute liver injury	[22]
	Liver fibrosis	HBV-LO2 cells	miR-222	TFRC	Inhibit the ferroptosis of LX2 cells and promote liver fibrosis and liver failure	[23]
	Steatotic liver IRI	HO-1/BMMSCs	miR-29a-3p	IREB2	Inhibit ferroptosis of steatotic liver IRI and improve liver tissue and cell injury	[24]
	Steatotic liver IRI	HO-1/BMMSCs	miR-124-3p	STEAP3		[25]
	Gastric carcinoma	CAFs	miR-522	ALOX15	Inhibit ferroptosis of gastric cancer cells and reduce chemotherapy sensitivity	[26]
	Gastric carcinoma	GC	lncFERO	hnRNPA1/SCD1	Inhibit ferroptosis of GCSC and enhance the chemotherapy resistance of GCSCs	[27]
	Colorectal carcinoma	Adipose cell	MTTP	PRAP1/ZEB1、GPX4/xCT	Inhibit ROS production and ferroptosis in CRC cells and promote tumor growth	[28]
	Pancreatic carcinoma	PANC	GOT1	Nrf2/HO-1	Inhibit ferroptosis of cancer cells and promote the development of tumors	[29]
Cardiovascular system	Acute myocardial infarction	HucMSC	miR-23a-3p	DMT1	Inhibit ferroptosis of cardiac myocyte and reduce myocardial injury	[30]
Cardiovascular system	Acute myocardial infarction	Pericardial adipose tissues	Adipsin	IRP2	Inhibit cardiomyocyte ferroptosis and maintain iron homeostasis	[31]
Nervous system	Cerebral hemorrhage	ADSC	miR-19b-3p	IRP2	Inhibit the ferroptosis of damaged brain cells and relieve symptoms	[32]
	Acute spinal cord injury	MSC	lncGm36569	miR-5627-5p/FSP1	Inhibit ferroptosis of neuronal cells and attenuate the neurological dysfunction caused by injury	[33]
	Cerebral IRI	BMMSC-EVs/Fer-1	Fer-1	GPX4/COX2	Inhibit ferroptosis of neurons and alleviate brain injury in mice	[34]
Respiratory system	Non-small cell lung cancer	NSCLC-cells	miR-4443	METTL3/FSP1	Inhibit ferroptosis of tumor cells and promote cisplatin resistance in NSCLC	[35]
	Lung adenocarcinoma	Plasma	cir93	AA/ACSL4、LPCAT3	Inhibit ferroptosis in lung adenocarcinoma cells and decrease lipid peroxidation in cancer cells	[36]
	Osteoporosis	EC	—	Ferritin	Inhibit ferroptosis of osteoblast and reverse the glucocorticoid-induced osteoporosis	[37]
Urinary System	Acute kidney injury	USC	lncTUG1	SRSF1/ACSL4	Inhibit ferroptosis of renal tubular epithelial cells and alleviate acute kidney injury	[38]
Others	UVB-induced skin injury	ADSC	circ-Ash1l	miR-700-5p/GPX4	Inhibit the ferroptosis of cells and improve UVB-induced skin damage	[39]
Others	Diabetic foot ulcer	BMMSC	circ-ITCH	TAF15/Nrf2	Inhibit ferroptosis of venous endothelial cells and promote angiogenesis and wound healing	[40]

MSC mesenchymal stem cell, HBV-LO2 cells HBV-infected LO-2 cells, HO-1/BMMSCs bone marrow mesenchymal stem cells by heme ox ygenase-1, CAFs cancer-associated fibroblasts, GC gastric cancer, PANC pancreatic cancer, ADSC adipose-derived stem cells, BMMSC-EVs/Fer-1 Fer-1 loaded bone marrow mesenchymal stem cell-derived extracellular vesicles, NSCLC non-small cell lung carcinoma, EC vascular endothelial cell, USC human urine-derived stem cells, OTUB1 deubiquitination, MTTP microsomal triglyceride transfer protein, GOT1 glutamic oxaloacetic transaminase 1, SCD1 stearoyl-Coa-desaturase, SRSF1 serine/arginine splicing factor 1, TAF15 TATA-Box binding protein associated factor 15, lncTUG1 lncRNA taurine-upregulated gene 1, circ-ITCH circRNA-itchy E3 ubiquitin protein ligase, cir93 circRNA_101093, hnRNPA1 heterogeneous nuclear ribonucleoprotein A1

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ISSN: 1478-811X

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