Table 5 Prospects for the clinical applications of piRNAs and PIWI proteins in drug resistance
From: Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
piRNA/PIWI proteins | Diseases | Role in cancers | Function | Functional mechanism | Ref. |
|---|---|---|---|---|---|
PIWIL1 | Multiple Myeloma | Carcinogen | Increase MM cell survival and promoted cell proliferation | Anti-autophagy and anti-mitophagy | [251] |
PIWIL1/piRNA-DQ593109 | Glioblastoma | Carcinogen | Decrease BTB Permeability | Decrease the concentration of chemotherapy drugs inside the tumor | [257] |
piR-39,980 | Neuroblastoma | Carcinogen | Induce the cancer cell growth, enhance metastasis, and inhibit the cellular senescence | Decrease the sensitivity of neuroblastoma to doxorubicin | [258] |
piR-39,980 | Fibrosarcoma | Tumor suppressor | Induce apoptosis and anti-proliferation effects | Increase sensitivity of fibrosarcoma to DOX | [119] |
piR-hsa-211,106 | Lung Adenocarcinoma | Tumor suppressor | Inhibit the proliferation and migration and promote apoptosis | Enhance the Chemotherapy Sensitivity of Cisplatin | [116] |
PIWIL2 | Cervical cancer | Carcinogen | Maintain the chemotherapy resistance of tumor initiation cells | Decrease the sensitivity of cisplatin in cervical cancer | [248] |
piR-1037 | OSCC | Carcinogen | Inhibit apoptosis | Decrease the sensitivity of OSCC to cisplatin | [114] |