Fig. 5
From: Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
The green targets in the figure are piRNAs/PIWI proteins that increase chemotherapy resistance. PIWIL1 inhibits the pro-apoptotic effect of chemotherapeutic drugs on MM cells by inhibiting mitochondrial apoptosis, thereby promoting proliferation and inhibiting apoptosis. PIWIL1/piR-DQ593109 can reduce the blood drug concentration in glioma by reducing the permeability of blood-tumor barrier, thus playing a role in chemotherapy resistance. piR-39,980, PIWIL2 and piR-1037 attenuated the efficacy of chemotherapy by reducing the sensitivity of tumor cells to chemotherapeutic drugs. piR-39,980 and piR-hsa-211,106 enhanced the chemotherapeutic effect by increasing the accumulation of chemotherapeutic drugs in tumor cells, thereby achieving anti-proliferation and pro-apoptosis effects