PKCδ regulates the vascular biology in diabetic atherosclerosis

Qin, Peiliang; He, Changhuai; Ye, Pin; Li, Qin; Cai, Chuanqi; Li, Yiqing

doi:10.1186/s12964-023-01361-4

Cell Communication and Signaling

Table 5 The role of PKC isoforms in diabetic atherosclerosis

From: PKCδ regulates the vascular biology in diabetic atherosclerosis

PKC isoforms	Working model	Pathophysiological processes
PKCα	PAECs	Increases endothelial permeability [133]
PKCα	A7r5 rat aortic VSMCs, human umbilical artery VSMCs, human aortic VSMCs	Inhibits serum withdrawal-induced VSMCs apoptosis [83]
PKCα	RAW 264.7, THP-1	Increases monocytes/macrophages-mediated inflammation [88, 97, 134]
PKCβ	Diabetic patients, capillary BRECs, BRPs	Increases vasoconstriction [30] Inhibits vasodilation [135]
PKCβ	BAECs, HAECs, HUVECs	Increases endothelial VCAM-1 and ICAM-1 expression, enhances plaque formation, complexity, and cholesterol content [137]
PKCβ	Human VSMCs	Mediates thrombin-stimulated VSMCs migration [72]
PKCβ	A7r5 rat aortic VSMCs, human umbilical artery VSMCs, human aortic VSMCs	Inhibits serum withdrawal-induced VSMCs apoptosis [83]
PKCβ	THP-1 cells, Raw 264.7, U937, diabetic ApoE-null mice	Increases monocytes/macrophages-mediated inflammation [134, 136, 137, 139]
PKCβ	Diabetic rats	Increases macrophages recruitment and ICAM-1 and MCP-1 protein expression in the kidney [138]
PKCδ	Capillary BRECs, BRPs, HUVECs, diabetic rats	Increases vasoconstriction [14, 29, 30] Inhibits vasodilation [13]
PKCδ	HRMECs, diabetic mice	Increases endothelial permeability [19]
PKCδ	HAECs, ECV 304, aortic segments from old mice	Mediates NADPH oxidase-dependent oxidant stress [42]
PKCδ	HUVECs	Increases endothelial apoptosis
PKCδ	Rat aortic VSMCs, human VSMCs	Promotes VSMCs migration and proliferation
PKCδ	Human VSMCs	Mediates thrombin-stimulated VSMCs migration [72]
PKCδ	RAW 264.7, THP-1, diabetic rats	Increases monocytes/macrophages-mediated inflammation [86, 88, 97]
PKCδ	Diabetic ApoE-null mice	Increases macrophages apoptosis and decreases their proliferation, alleviates plaque progression and splenomegaly [85]
PKCδ	Tsc1- null MEFs	Increases LDLR expression [115]

PAECs Porcine aortic endothelial cells, BRECs Bovine retinal endothelial cells, BRPs Bovine retinal pericytes, BAECs Bovine aortic endothelial cells, HAECs Human aortic endothelial cells, HUVECs Human umbilical vein endothelial cells, ICAM-1 Intercellular cell adhesion molecule-1, VCAM-1 Vascular cell adhesion molecule-1, MCP-1 Monocyte chemoattractant protein-1, HRMECs Human retina microvascular endothelial cells, NADPH Nicotinamide adenine dinucleotide phosphate, MEFs Mouse embryonic fibroblasts, LDLR Low density lipoprotein receptor

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ISSN: 1478-811X

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