Table 3 Animal studies indicating the role of PKCδ in regulating the function of monocytes/macrophages
From: PKCδ regulates the vascular biology in diabetic atherosclerosis
Pathophysiological process | Group 1 | Group 2 (vs. group 1) | Group 3 (vs. group 1) | Group 4 (vs. group 3) | |
|---|---|---|---|---|---|
Rodents with DM | - | - | + | + | |
PKC δ KO/KD rodents | - | + | - | + | |
Macrophages PKCδ expression | Base | Decrease | Increase [85] | Decrease | |
Macrophages proinflammatory biomarker expression | Base | Not mentioned | Not mentioned | Decrease [86] | |
Macrophages uptake of oxLDL | Base | No change [87] | Not mentioned | Not mentioned | |
Foam cell formation | Base | No change [87] | Not mentioned | Not mentioned | |
Atherosclerotic lesions | Base | Increase [85] | Not mentioned | Increase [85] | |
Splenomegaly | Base | Increase [85] | Not mentioned | Increase [85] | |
Macrophages number in aortic plaque/spleen | Base | Increase [85] | Not mentioned | Increase [85] | |
Macrophages apoptosis in aortic plaque/spleen | Base | Decrease [85] | Not mentioned | Decrease [85] | |
Macrophages proliferation in aortic plaque/spleen | Base | Increase [85] | Not mentioned | Increase [85] | |
Monocytes uptake into arterial wall | Base | No change [85] | Not mentioned | No change [85] | |
Inflammatory cytokines expression in aortic plaque | Base | Increase [85] | Not mentioned | Increase [85] |