Table 1 Animal studies indicating the role of PKCδ in regulating the function of endothelial cells
From: PKCδ regulates the vascular biology in diabetic atherosclerosis
Pathophysiological process | Group 1 | Group 2 (vs. group 1) | Group 3 (vs. group 1) | Group 4 (vs. group 3) | |
|---|---|---|---|---|---|
Rodents with DM | - | - | + | + | |
PKCδ KO/KD rodents | - | + | - | + | |
Endothelial PKCδ expression | Base | Decrease | Increase [13] | Decrease | |
Vasodilation (tissue) | Base | Not mentioned | Decrease [13] | Increase [13] | |
Vasoconstriction (tissue) | Base | Not mentioned | Increase [14] | Decrease [14] | |
Inflammatory cell infiltration | Base | Decrease [15] Increase [16] | Not mentioned | Not mentioned | |
Neutrophils adhesion | Base | Decrease [17] | Not mentioned | Not mentioned | |
Neutrophils migration | Base | Decrease [17] | Not mentioned | Not mentioned | |
Tight junction protein expression | Base | Increase [18] | Decrease [19] | Increase [19] | |
Hyperpermeability | Base | Decrease [18] Increase [16] | Increase [19] | Decrease [19] |