New insights into the regulation of METTL3 and its role in tumors

Table 1 Effect of different noncoding RNAs on METTL3 expression

Cell or Tissue	Source	Noncoding RNA	Effects	In vitro/vivo	Animal experiments	Reference
Breast cancer	SUM-1315, MCF-7	miR-483-3p	Inhibition	In vitro	Not involved	[32]
	MCF-7	Let-7 g	Inhibition	In vitro	Not involved	[33]
	MDA-MB-231, BT-549	miR-34c-3p	Inhibition	In vitro	Not involved	[34]
Melanoma	SKMEL, HT-144	miR-302a-3p	Inhibition	In vitro	Not involved	[35]
Gastric cancer	AGS, MGC-803	miR-193b-5p	Inhibition	In vitro	Not involved	[36]
	HCG-27, MGC-803	miR-4429	Inhibition	In vitro	Not involved	[37]
	NCI-N87, SNU-16	miR-1269b	Inhibition	In vitro	Not involved	[38]
	SCG-7901, BGC-823	miR-338-5p	Inhibition	In vitro	Not involved	[39]
NSCLC	A549, NCI-H460	miR-33a	Inhibition	In vitro	Not involved	[40]
	A549, H1299	miR-600	Inhibition	In vitro	Not involved	[41]
	A549-S, A549-R	miR-4443	Inhibition	Both	Xenograft tumor model in nude mice	[42]
	A549, H1650	miR-590-5p	Inhibition	In vitro	Not involved	[43]
	H1299/DDP, A549/DDP	miR-524-5p	Inhibition	In vitro	Not involved	[30]
Hepatocellular carcinoma	HepG2, HuH-6	miR-186	Inhibition	Both	Xenograft tumor model in mice	[44]
	Hep3B	miR24-2	Promotion	In vitro	Not involved	[45]
	Hep3B	miR-1301-3p	Inhibition	In vitro	Not involved	[46]
Nasopharyngeal Carcinoma	KY-SE150, Eca-9706	miR-186-5p	Inhibition	In vitro	Not involved	[47]
M1 macrophages	LN‐229	miR-302a	Inhibition	In vitro	Not involved	[29]
Human Cartilage Tissues	Osteoarthritis Samples	miR-373	Inhibition	In vitro	Not involved	[48]
HRVEC		tRF-1001	Inhibition	Both	OIR mouse model	[49]
AML	Bone marrow samples of AML patients Molm13, HL-60	miR-493-5p	Inhibition	In vitro	Not involved	[32]

ISSN: 1478-811X