Fig. 5
From: Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer
Simvastatin trigged colon cancer cell pyroptosis through activating ROS/NLRP3/Caspase-1 axis. A The rate of ROS-positive cells in different groups of cells. B Levels of NLRP3, ASC, pro-caspase1, cleaved-caspase1, pro-IL-1β, mature-IL-1β, IL-18, GSDMD, GSDMD-N were detected by western blotting analysis in different groups of cells, with β-actin as the reference protein. *, p < 0.05