Fig. 2
From: Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer
Simvastatin induced pyroptosis in HCT116 and SW620 cells. A After treating with simvastatin for 24 h, pyroptosis rate of cells was detected by flow cytometry analysis. B Levels of NLRP3, ASC, pro-caspase-1, cleaved-caspase-1, pro-IL-1β, mature-IL-1β, IL-18, GSDMD and GSDMD-N were detected by western blotting analysis in simvastatin treated and untreated cells, with β-actin as the reference protein. *, p < 0.05