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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma

Fig. 7

SOR and DKK1 inhibitor treatment inhibited PI3K/Akt and Wnt/β-catenin pathways. Combination treatment of SOR and DKK1 inhibitor decreased the expression of p110α, p-Akt and p-GSK3β-ser9, better than SOR treatment alone in vitro and in vivo. Subsequently, elevated expression of p-GSK3β-Tyr216 induced β-catenin degradation and decreased β-catenin target gene levels

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Cell Communication and Signaling

ISSN: 1478-811X