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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma

Fig. 3

SOR + WAY treatment induced cell apoptosis and cell arrest in HCC cells. Huh7 and Hep3B cells were treated with IC50 values of SOR and/or WAY for 24 h. A Apoptotic cells were measured using flow cytometric analysis. B Apoptosis-related proteins were detected using western blot analysis in Huh7 and Hep3B cells. C, D Cell cycle analysis of SOR, WAY and their combination in Huh7 and Hep3B cells. E Heatmaps of differentially expressed cell cycle associated genes in Huh7 and Hep3 cells. F qRT-PCR analysis of cell cycle associated genes in Huh7 and Hep3B cells. Data are presented as the mean ± SD and performed in triplicate independently. Statistical significance is indicated by *P < 0.05, **P < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X