Fig. 2
From: A state-of-the-art review on the NRF2 in Hepatitis virus-associated liver cancer
Liver CSC properties and NRF2's function in the liver. By regulating downstream enzymes and transporter members, Nrf2 enhances drug metabolism and drug resistance, triggers a DNA damage response, and plays a role in the development of specific stem cells. Here, we summarize the research on NRF2 and its impact on CSCs' stemness, self-renewal capacity, tumorigenesis, and chemoresistance [67]