IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells

Table 1 Lung adenocarcinoma cells and driver mutation

	Cell line (Male/ female)	Mutation	*IL1R1* mRNA	*IL1Racp* mRNA	*IDO1* Response to IL-1β	*CXCL8* response to IL-1β
NSCLC Adenocarcinoma	A549 (M)	KRAS, LKB mutant	+ + + +	+ +	+ +	+ + +
	H1792 (M)	KRAS mutant	+ + + +	+ + +	+ + + + + +	+ + + + + +
	H1838 (F)	EGFR Amplification	+ + +	+ + +	+ +	+ +
	H2347 (F)	NRAS mutant	+ + +	+ + +	+ + +	+ + + +
	HCC364 (M)	BRAF^V600E mutant	+ + + + +	+ + +	+ + +	+ + + +
	HCC827 (F)	EGFR mutant	+ + +	+ + + +	+ + + +	+ +
	H2228 (F)	EML4-ALK1 fusion	+ + +	+ + + + + +	-	+ + +
Immortalized Normal cells	HBEC-3KT	Non-cancerous lung epithelial cells Immortalized with CDK4 and hTERT	+	+ + + +	-	+
Immortalized Normal cells	HSAEC-1KT	Non-cancerous lung epithelial cells Immortalized with CDK4 and hTERT			-	+

ISSN: 1478-811X