Fig. 10
From: Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration
Autophagy-modulated biomaterials promote heart regeneration. a Baseline left ventricular ejection fraction of mdx and wild-type mice before treatment. b Improvement in cardiac function after treatment with rapamycin-loaded nanoparticles. c Western blotting of LC3I, LC3II, p62 and BNIP3 in the hearts of mdx mice treated with rapamycin-loaded nanoparticles. Reproduced with permission. [156] Copyright 2014, John Wiley and Sons. d Schematic illustration of the role of M-MSN@NAC in reducing oxidative injury and apoptosis by downregulating autophagy in cardiomyocytes stimulated with hypoxia and reoxygenation [155]