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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation – A meta-analysis

Fig. 7

Survival functions for different expression levels of DNAJB4, CAPN7, DSG2, ECH1. The figure shows 4 exemplary proteins selected from the members of the invasion and proliferation panel and their impact on patients’ survival. a DNAJB4, which we found to be positively associated with invasion and which the Human Protein Atlas (HPA) suggests that its high expression is associated with a worse prognosis in kidney tumors (n = 877). b CAPN7 protein, which in our study is negatively associated with invasion and which the HPA suggests may be associated with a favorable prognosis in kidney tumors. c DSG2 protein which in our study positively predicted the proliferation capacity is a negative prognostic factor in CNS tumors, based on HPA. d Based on our results, ECH1 protein negatively predicted the proliferation capacity, and it is a favorable prognostic marker for CNS tumors

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Cell Communication and Signaling

ISSN: 1478-811X