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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation – A meta-analysis

Fig. 3

Biological signaling pathways affected by the 172 selected proteins of the discriminative protein panel. The columns marked with different colors represent the 60 EV samples, while the rows indicate the various signaling pathways. Both the 60 samples and pathways were clustered hierarchically. The heatmap values represent the average intensity of the proteins that are part of a given signal pathway. The gray barplots next to the names of the pathways indicate the -log10(p value). In all instances, p < 0.05. (agg.: aggregation; biosynth.: biosynthesis; cotrans.: cotransporters; deacet.: deacetylate; form.: formation; mod.: modifying; org.: organization; phosph.: phosphorylation; prots.: proteoglycans; sig.: signaling; trans.: transcription; transl.: translocation)

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Cell Communication and Signaling

ISSN: 1478-811X