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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: FTO facilitates cancer metastasis by modifying the m6A level of FAP to induce integrin/FAK signaling in non-small cell lung cancer

Fig. 6

Integrin signaling is involved in FAP-induced FAK pathway activation. a Functional analysis of FAP with FunRich software showed that FAP was associated with the integrin family. Data were obtained from the TCGA database. b FAP and integrin α3β1 interactions were detected in NSCLC cells by co-IP assays. c-e Knockdown of integrin β1 inhibited FAP-induced cell migration and invasion. Quantitative analysis of Transwell and wound healing assay data in NSCLC cells are shown. f–h Knockdown of integrin α3 inhibited FAP-induced cell migration and invasion. Quantitative analysis of Transwell and wound healing assay data in NSCLC cells are shown. i Knockdown of integrin β1 blocked FAP-induced activation of the FAK signaling pathway in NSCLC cells. j Knockdown of integrin α3 blocked FAP-induced activation of the FAK signaling pathway in NSCLC cells. Data information: Data are shown as the mean ± SDs. In all relevant panels, *P < 0.05; **P < 0.01; ***P < 0.001

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Cell Communication and Signaling

ISSN: 1478-811X