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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: FTO facilitates cancer metastasis by modifying the m6A level of FAP to induce integrin/FAK signaling in non-small cell lung cancer

Fig. 5

FTO activates the FAK signaling pathway through FAP. a GSEA based on the TCGA dataset showed that high expression of FAP was associated with focal adhesion. ES, enrichment score. NES, normalized enrichment score. FDR, false discovery rate. b Western blot analysis showed that FAP can affect FAK signaling. c-e The FAK-inhibitor defactinib (VS6063) inhibited the FAP-induced cell migration and invasion. Quantitative analysis of Transwell and wound healing assay data in NSCLC cells are shown. f–h Knockdown of FTO inhibited the FAP-induced cell migration and invasion. Quantitative analysis of Transwell and wound healing assay data in NSCLC cells are shown. i The FAK-inhibitor (VS6063) blocked FAP-induced activation of the FAK signaling pathway in NSCLC cells. j Knockdown of FTO rescued FAP-induced activation of the FAK signaling pathway in NSCLC cells. Data information: Data are shown as the mean ± SDs. In all relevant panels, *P < 0.05; **P < 0.01; ***P < 0.001

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Cell Communication and Signaling

ISSN: 1478-811X