Fig. 9

Schematic representation of putative mechanisms underlying indacaterol effects on MDA-MB-231 cell migration. Each impacted pathway is symbolized with a different color and a letter has also been assigned to help the explanation in the text. ADRB2/ β2 AR: adrenergic receptor β2; AKT: protein kinase B; ALIX: programmed cell death 6-interacting protein; AMP: adenosine monophosphate; AS: alternative splicing; ATP: adenosine triphosphate; ATXN2: ataxin 2; cAMP: cyclic adenosine monophosphate; CAV1: caveolin 1; DAG: diacylglycerol; ECM: extracellular matrix; ESCRTs:endosomal sorting complex required for transport; Gi: inhibitory G-protein; Gp: Gp protein alpha subunit; GPCR: G protein-coupled receptor; Gs: stimulatory G-protein; IP3: inositol trisphosphate; ITGA5: integrin alpha 5; ITGB3: integrin beta 3; LAMP1: lysosomal-associated membrane protein 1; LE: late endosome; M2: muscarinic receptors 2; M3: muscarinic receptors 3; MAP2: microtubule-associated protein 2; MLCP: myosin light-chain phosphatase; mTor: mechanistic target of rapamycin; MVB: multivesicular bodies; PDE: phosphodiesterase; PI3K: phosphoinositide 3-kinase; PKA: protein kinase A; PKC: protein kinase C; PKG: protein kinase G; RABs: Rab G-protein; SRSF6: splicing factor, arginine/serine-rich 6