p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics

Ahmadi, Ali; Ahrari, Sajjad; Salimian, Jafar; Salehi, Zahra; Karimi, Mehrdad; Emamvirdizadeh, Alireza; Jamalkandi, Sadegh Azimzadeh; Ghanei, Mostafa

doi:10.1186/s12964-023-01337-4

Cell Communication and Signaling

Table 3 Genes and proteins that are affected downstream of p38 signaling within in vivo models of COPD

From: p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics

Gene	Source	Treatment	Case/control	Up/down^a	Ref
MMP-12	COPD model in Mice (BALF sample)	CS + LPS	CS + LPS/PBS	Up-P	[147]
	Emphysema mice model (BALF sample)	CS + LPS	Emphysema mice/WT	Up-P	[147]
	Lung tissue (emphysema mice model)	CS + SB203580	CS + SB203580/CS	Down-G	[148]
IL-16	COPD model in Mice (BALF sample)	CS + LPS	CS + LPS/PBS	Up-P	[147]
IL-16	Emphysema mice model (BALF sample)	CS + LPS	Emphysema mice/WT	Up-P	[147]
IL-27	COPD model in Mice (BALF sample)	CS + LPS	CS + LPS/PBS	Up-P	[147]
IL-27	Emphysema mice model (BALF sample)	CS + LPS	Emphysema mice/WT	Up-P	[147]
Leptin	COPD model in Mice (BALF sample)	CS + LPS	CS + LPS/PBS	Up-P	[147]
Leptin	Emphysema mice model (BALF sample)	CS + LPS	Emphysema mice/WT	Up-P	[147]
TCA-3	COPD model in Mice (BALF sample)	CS + LPS	CS + LPS/PBS	Up-P	[147]
TCA-3	Emphysema mice model (BALF sample)	CS + LPS	Emphysema mice/WT	Up-P	[147]
KC (CXCL-1)	COPD model in Mice (BALF sample)	CS + LPS	CS + LPS/PBS	Up-P	[147]
	Emphysema mice model (BALF sample)	CS + LPS	Emphysema mice/WT	Up-P	[147]
	Lung tissue (emphysema mice model)	CS + SB203580	CS + SB203580/CS	Down-G	[55]
CRP	Emphysema mice model (BALF sample)	CS + LPS	Emphysema mice/WT	Up-P	[147]
	Circulating chemokine (COPD GOLD II)	GW856553	GW856553/Plasebo	Down-P	[149]
	Human COPD (GOLD II/III)	PH-797804	PH-797804/Placebo	Down-P	[55]
ITAC	Emphysema mice model (BALF sample)	CS + LPS	Emphysema mice/WT	Up-P	[147]
Adiponectin	Emphysema mice model (BALF sample)	CS + LPS	Emphysema mice/WT	Up-P	[147]
Prolactin	Emphysema mice model (BALF sample)	CS + LPS	Emphysema mice/WT	Up-P	[147]
uPAR	Emphysema mice model (BALF sample)	CS + LPS	Emphysema mice/WT	Up-P	[147]
FAM-174A	Whole blood (Human COPD)	Dilmapimod	Dilmapimod/placebo	Down-G	[54]
ADM	Whole blood (Human COPD)	Dilmapimod	Dilmapimod/placebo	Down-G	[54]
CCL-8	Whole blood (Human COPD)	Dilmapimod	Dilmapimod/placebo	Down-G	[54]
CXCL-1	Whole blood (Human COPD)	Dilmapimod	Dilmapimod/placebo	Down-G	[54]
IL-1β	Whole blood (Human COPD)	Dilmapimod	Dilmapimod/placebo	Down-G	[54]
IL-1β	Lung tissue (emphysema mice model)	CS + SB203580	CS + SB203580/CS	Down-G	[55]
TLR-1	Whole blood (Human COPD)	Dilmapimod	Dilmapimod/placebo	Down-G	[54]
ZNF-519	Whole blood (Human COPD)	Dilmapimod	Dilmapimod/placebo	Down-G	[54]
MMP-9	Whole blood (Human COPD)	Dilmapimod	Dilmapimod/placebo	Down-G	[54]
MMP-9	Guinea Pig BAL fluid	SB 239063 + LPS	SB 239063 + LPS/LPS	Down-P	[40]
COX-2	CS exposed rat	MSC + CS	MSC + CS/CS	Down-P	[39]
PGE-2	CS exposed rat	MSC + CS	MSC + CS/CS	Down-P	[39]
CXCL-8	Septum (human COPD)	-	COPD/healthy	Up-G&P	[143]
MMP-2	Lung tissue (emphysema mice model)	CS + SB203580	CS + SB203580/CS	Down-G	[55]
TNFα	Lung tissue (emphysema mice model)	CS + SB203580	CS + SB203580/CS	Down-G	[55]
	alveolar macrophages (COPD GOLD IV)	LPS + AZD7624	COPD/healthy	Down-P	[144]
	Rat whole blood	SB-239063 + LPS	SB 239063 + LPS/LPS	Down-P	[40]
MIP-1α	Lung tissue (emphysema mice model)	CS + SB203580	CS + SB203580/CS	Down-G	[55]
IL-6	Lung tissue (emphysema mice model)	CS + SB203580	CS + SB203580/CS	Down-G	[55]
	AMs (COPD GOLD IV)	LPS + AZD7624	COPD/healthy	Down-P	[144]
	Circulating chemokine (COPD GOLD II)	GW856553	GW856553/Placebo	Down-P	[149]
	Guinea Pig BAL fluid	SB-239063 + LPS	SB 239063 + LPS/LPS	Down-P	[40]
Fibrinogen	Circulating chemokine (COPD GOLD II)	GW856553	GW856553/Placebo	Down-P	[149]
IL-8	Circulating chemokine (COPD GOLD II)	GW856553	GW856553/Placebo	Down-P	[149]
HSP-27	Circulating chemokine (COPD GOLD II)	SB-681323	SB-681323/Placebo	Down-P	[44]

^aDown Downregulation, Up Upregulation, P Protein, G Gene

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ISSN: 1478-811X

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