p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics

Table 2 Genes and proteins that are affected downstream of P38 signaling within in vitro models of COPD

Gene	Source	Treatment	Case/control	Up/down^a	Ref
IL-8	16HBE Cell line	H₂O₂/TNF-α + IL-1β + INFγ/LPS	H2O2/TNF-α + IL-1β + INFγ/LPS vs. baseline	Down-G	[50]
NFkB p65	16HBE Cell line	H2O₂/TNF-α + IL-1β + INFγ/LPS	H2O2/TNF-α + IL-1β + INFγ/ baseline with LPS	Down-G	[50]
IL-10	MH-S cell line	GOLD III/IV serum + LPS + SB203580	GOLD III/IV serum + LPS + SB203580/ GOLD III/IV serum + LPS	Up-P	[43]
CCL-5	MH-S cell line	GOLD IV COPD serum + LPS + SB203580	GOLD III and IV COPD serum + LPS + SB203580/ GOLD III and IV COPD serum + LPS	Down-P	[43]
TNFα	MH-S cell line	GOLD III and IV COPD serum + LPS + SB203580	GOLD III and IV COPD serum + LPS + SB203580/ GOLD III and IV COPD serum + LPS	Down-P	[43]
GRP-78	A549 cells	SB203580 + CS	SB203580 + CS/CS	Down-G&P	[81]

ISSN: 1478-811X