Table 1 Genes and proteins that are affected downstream of p38 signaling within ex vivo models of COPD
From: p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics
Gene | Source | Treatment | Case/Control | Up/Downa | Ref |
|---|---|---|---|---|---|
INFγ | CD8 cells (human) | S100 + IL12 + IL8 | S100 + IL12 + IL8/ IL12 + IL8 | Down-P | [23] |
MDM cells (human COPD) | Dexab + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] | |
IL-6 | Epithelial cells (human COPD) | S100 + polyinosinic: polycytidylic acid | S100 + I:P/I:P | Down-P | [23] |
Alveolar macrophages (AMs) | LPS + Dexa + BIRB-796 | LPS + Dexa + BIRB-796/LPS | Down-P | [38] | |
Macrophages (CS exposed rat) | MSC + CS | MSC + CS/CS | Down-G | [39] | |
Guinea Pig AMs | SB 239063 + LPS | SB 239063 + LPS/LPS | Down-P | [40] | |
CXCL-8 | AMs (human COPD) | BIRB-796 + LPS | BIRB-796 + LPS/LPS | Down-P | [41] |
Epithelial cells (human COPD) | S100 + I:P | S100 + I:P/I:P | Down-P | [23] | |
PBMCs (COPD human) | LPS + Dexa + GW856553 | Down-P | [42] | ||
CCL-5 | Epithelial cells (human COPD) | S100 + I:P | S100 + I:P/I:P | Down-P | [23] |
PBMCs (human COPD IV) | SB203580 + LPS | SB203580 + LPS/LPS | Down-P | [43] | |
TNFα | Blood neutrophils (human COPD) | S100 + LPS | S100 + LPS/basal | Down-P | [23] |
AM cells (human COPD) | BIRB-796 + LPS | BIRB-796 + LPS/LPS | Down-P | [41] | |
Alveolar macrophages | LPS + Dexa + BIRB-796 | LPS + Dexa + BIRB-796/LPS | Down-P | [38] | |
Whole blood (COPD GOLD II) | SB-681323 + LPS | SB-681323 + LPS/Placebo + LPS | Down-P | [44] | |
PBMCs (human COPD IV) | SB203580 + LPS | SB203580 + LPS/LPS | Up-P | [43] | |
IL-10 | Macrophages (CS exposed rat) | MSC + CS | MSC + CS/CS | Up-G | [39] |
PBMCs (human COPD IV) | SB203580 + LPS | SB203580 + LPS/LPS | Up-P | [43] | |
MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] | |
Alveolar macrophages | LPS + Dexa + BIRB-796 | LPS + Dexa + BIRB-796/LPS | Down-P | [38] | |
iNOS | Macrophages (CS exposed rat) | MSC + CS | MSC + CS/CS | Down-G | [39] |
COX-2 | Macrophages (CS exposed rat) | MSC + CS | MSC + CS/CS | Down-G | [39] |
PGE-2 | Macrophages (CS exposed rat) | MSC + CS | MSC + CS/CS | Down-G | [39] |
CCL7 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
TNFSF-9 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
CSF-2 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
CCL-2 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
TNFSF-15 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
TNFSF-4 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
IL-12B | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
TNF | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
CXCL-10 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
IL-27 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
CLCF-1 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
OSM | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
CCL-8 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
IL-6 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
IL-1A | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
CXCL-9 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
CXCL-2 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
CXCL-3 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
CXCL-1 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
IL-8 | MDM cells (human COPD) | Dexa + SB706504 + LPS | LPS/Dexa + SB706504 + LPS | Down-G | [37] |
Alveolar macrophages | LPS + Dexa + BIRB-796 | LPS + Dexa + BIRB-796/LPS | Down-P | [38] | |
GM-CSF | Alveolar macrophages | LPS + Dexa + BIRB-796 | LPS + Dexa + BIRB-796/LPS | Down-P | [38] |
IL-1ra | Alveolar macrophages | LPS + Dexa + BIRB-796 | LPS + Dexa + BIRB-796/LPS | Down-P | [38] |
MDC | Alveolar macrophages | LPS + Dexa + BIRB-796 | LPS + Dexa + BIRB-796/LPS | Down-P | [38] |