Fig. 2
From: Function and regulation of RGS family members in solid tumours: a comprehensive review
Classical RGS subfamily and related structural domains. Based on the RGS homology and structural domains, the classical RGS proteins were divided into four subfamilies. The four subfamilies are RGS A/RZ, B/R4, C/R7 and D/R12, and the members of each subfamily are also listed in the figure. Each subfamily contains a G protein-specific RGS domain (RH), the "RGS Box", which acts on the Gα subunit and exhibits GAP activity, in addition to the cysteine string (CYS) in the RGS A/RZ subfamily. R4 subfamily RGS3 also has the domains of PSD-95, Dlg, and ZO-1/2 (PDZ); the R7 subfamily also contains the Dishevelled/EGL10/pleckstrin domain (DEP) and G-protein γ-like domain (GGL); and the R12 subfamily contains the phosphotyrosine-binding domain (PTB), Raf-like Ras-binding domain (RBD) and G-protein regulatory motif (GoLoco) in addition to the PDZ structural domain