Fig. 1
From: Function and regulation of RGS family members in solid tumours: a comprehensive review
The canonical regulation pattern of GPCR signalling by RGS proteins. When G protein-coupled receptors (GPCRs) specifically recognize and bind to agonists, GPCRs cause conformational changes that promote the activation of Gα-GDP on the α subunit of the heterotrimer complex in exchange for free GTP, plus the release of Gβγ dimers that can all continue to conduct some downstream signals or effectors. RGS proteins are Gα-GTP hydrolase accelerator proteins (GAPs) that can terminate the signal transduction of GPCRs by promoting Gα-GTPase activity and GTP hydrolysis inactivation after interchanging with GDP and promoting the heterotrimer complex Gβγ to recombine with the receptor on the cell membrane