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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Peroxiredoxin II regulates exosome secretion from dermal mesenchymal stem cells through the ISGylation signaling pathway

Fig. 8

Proposed model for the role of Prx II in regulating exosome secretion from DMSCs. Prx II deletion results in a decrease in Foxo1 level in the nucleus by downregulating JNK activity. This decrease increases the expression of miR-221, which negatively regulates the expression of STAT1 and STAT2 to induce ISGylation, promoting exosome secretion from DMSCs

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Cell Communication and Signaling

ISSN: 1478-811X