Fig. 1

NK cells in the CNS. Conventional NK cells are divided into CD56^dim and CD56^bright groups. The CD56^dim cells predominantly circulate in the peripheral blood, whereas the CD56^bright subset chiefly populates the CSF. In the steady state of CNS, cNK cells are localized within the meninges while tissue-resident NK cells or ILC1s reside in the choroid plexus and meninges. In disease states, brain-resident cells, like neurons, microglia, astrocytes and endothelia cells, are able to release different chemokines to guide NK cells in their infiltration into the brain parenchyma. (Created with BioRender.com)