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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Inhibition of USP7 upregulates USP22 and activates its downstream cancer-related signaling pathways in human cancer cells

Fig. 8

Hypothetic schematic model of response to USP7 inhibition and therapeutic benefits of targeting both USP7 and USP22 in human cancer. Upregulation of USP22 upon USP7 inhibition may activate downstream signaling pathways of USP22 such as c-Myc and H2Bub1 as well as FOXP3 (data not shown) and PD-L1 (data not shown) in cancer cells, which may antagonize antitumor activity of USP7 in human cancer cells, while targeting both USP7 and USP22 will induce broad and synergistic anti-cancer effects

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Cell Communication and Signaling

ISSN: 1478-811X