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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status

Fig. 1

Cardiac glycosides induce apoptosis in a panel of human AML-derived cells. A Structures of digoxin, user-designed digitoxin analog D6-MA, and ouabain. B − D Dose–response curves generated from the percentage of apoptosis as evaluated by Annexin V/7-AAD assay after cardiac glycoside treatment (0 − 300 nM) for 48 h in various human AML-derived cells, including KG-1 (M0) (B), HL-60 (M2) (C), and PL-21 (M3) (D) cells. LC50 were then calculated from the plots and compared among different AML cells and treatments. Data are mean ± SD (n = 3)

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Cell Communication and Signaling

ISSN: 1478-811X