Fig. 1
From: Targeting CD24 as a novel immunotherapy for solid cancers
The schematic summarizes known interactions between CD24 on tumor cells and its associated ligands on immune cells at the level of surface molecules. The interaction between CD24 on cancer cells and (1) Siglec-G/10 on macrophages to inhibit phagocytosis by macrophages, (2) P-/E-selectin on endothelium and (3) L1CAM on leukocyte results in inhibitory signal cascades, thus, tumor cells cannot be cleared