Fig. 1

Single-cell transcriptomic landscape of HPSCC. a Schematic diagram of the experimental design and analysis. b UMAP plot of the clustering of 67,025 cells from all eight tumor and adjacent normal tissues samples, color coded by cell type (left), sample type (middle), or patient origin (right). c Heatmap showing signature DEGs between different cell types in HPSCC. d Bar plots showing the proportion of 11 major cell types for different donors (left) and tissues (right). e Frequency per cell type in tumor and adjacent normal tissue samples