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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: L-Fucose promotes enteric nervous system regeneration in type 1 diabetic mice by inhibiting SMAD2 signaling pathway in enteric neural precursor cells

Fig. 3

 L-Fucose enhanced ENPCs-derived neurogenesis and gliogenesis in T1DM mice. A Representative immunofluorescence confocal laser images of neurons (HuC/D, red) co-expressed GFP (green) in colonic myenteric plexus in each group; the nuclei (blue). Arrows represent double-labeled HuC/D+ GFP+ neurons. B The proportion of HuC/D+ GFP+ neurons (newly formed neurons from ENPCs) in the colonic myenteric plexus in each group (n = 4). C Representative immunofluorescence confocal laser images of glial cells (GFAP, red) co-expressed GFP (green) in colonic myenteric plexus in each group; the nuclei (blue). Arrows represent double-labeled GFAP+ GFP+ glial cells. D The proportion of GFP+ GFAP+ glial cells (newly formed glial cells from ENPCs) in the colonic myenteric plexus in each group (n = 4). Con: the control mice; Fuc: control mice administrated with L-Fucose; DM: diabetic mice; DM + Fuc: diabetic mice administrated with L-Fucose; ENPCs, enteric neural precursor cells; T1DM, type 1 diabetes mellitus. Results were expressed as mean ± standard deviation. **p < 0.01, ****p < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X