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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: L-Fucose promotes enteric nervous system regeneration in type 1 diabetic mice by inhibiting SMAD2 signaling pathway in enteric neural precursor cells

Fig. 1

 L-Fucose promoted the recovery of gastrointestinal motility in T1DM mice. A Defecation frequency (n = 6). B Total intestinal transmission time (n = 6). C Bead expulsion time (n = 6). D Representative basal curves of isometric tension of colonic muscle strip. Comparison of the motility index (E), frequency (F), and amplitude (G) of colonic muscle strip in each group (5 min) (n = 4). H Representative schematic diagram of colonic muscle strip contraction in response to EFS at different frequencies in each group (2–64 Hz). I Quantification of colonic muscle strip contraction in response to EFS in each group (n = 3). Con: the control mice; Fuc: control mice administrated with L-Fucose; DM: diabetic mice; DM + Fuc: diabetic mice administrated with L-Fucose; T1DM, type 1 diabetes mellitus; EFS, electrical field stimulation. Results were expressed as mean ± standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X