Fig. 2

Intercellular communication that EV cargoes mediate regulates the cerebrovascular disease progression

Cargoes from different donor cells, including neurons, microglia, astrocytes, mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), adipose-derived stem cells (ADSCs), and hippocampal neural stem cells (HNSCs) can activate or inhibit specific targets in recipient cells during cerebrovascular disease progression, including ischemic stroke (IS), intracerebral hemorrhage (ICH), vascular dementia (VD), and cerebral small vessel disease (CSVD). These processes promote or inhibit the physiological and pathological processes of cerebrovascular diseases, and blocking the delivery of miR-383-3p and miR-154-5p can improve ICH and VD. Further studies on intercellular communication that EV cargoes mediate in CSVD are needed