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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential

Fig. 1

Extracellular vesicle (EV) biogenesis and intercellular communication between donor and recipient cells that EVs mediate

Multiple small vesicles originating from the endosome membrane and sprouting inward are defined as intraluminal vesicles (ILVs). Endosomes containing ILVs are called multivesicular bodies (MVBs). The MVBs subsequently fuse with the plasma membrane to release ILVs into the extracellular space to form exosomes. Microvesicles and apoptotic bodies are generally large and can be directly formed by plasma membrane budding. EVs in circulation carry various cargo types, such as CD9, CD63, CD81, and microRNAs, and enter donor cells by fusion, signal recognition, and phagocytosis

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Cell Communication and Signaling

ISSN: 1478-811X