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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Transgenerational inheritance of adrenal steroidogenesis inhibition induced by prenatal dexamethasone exposure and its intrauterine mechanism

Fig. 7

Effects of PDE on adrenal H19/let-7c axis and steroidogenesis in female offspring rats of F3 generation A Bodyweight; B Serum CORT concentration; C Adrenal StAR mRNA expression; D E Adrenal StAR protein expression; F Adrenal CTCF mRNA expression; G H Adrenal CTCF protein expression (immunohistochemistry staining with brown, × 400); I J Adrenal methylation status of individual DNA strands of H19 DMR containing 10 CpG sites and average methylation ratio in each CpG site; K Adrenal H19 mRNA expression; L Adrenal let-7c expression. Mean ± S.E.M., n = 12 for mRNA detection, n = 3 for immunohistochemistry detection and BSP. *p < 0.05, **p < 0.01 vs. control. PDE, prenatal dexamethasone exposure; CORT, corticosterone; StAR, steroidogenic acute regulatory protein; CTCF, CCCTC binding factor

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Cell Communication and Signaling

ISSN: 1478-811X