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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Transgenerational inheritance of adrenal steroidogenesis inhibition induced by prenatal dexamethasone exposure and its intrauterine mechanism

Fig. 3

Effects of DEX on StAR expression and related H19/let-7b axis in NCI-H295R cells. A cell viability with 500 nM DEX treatment in different time; B cell viability with different concentrations of DEX treatment for 24 h; C StAR mRNA expression with DEX different concentrations; D StAR mRNA expression with DEX different time; E GR mRNA expression; F CTCF mRNA expression; G Dnmt3a and Dnmt3b mRNA expression; H I methylation status of individual DNA strands of H19 DMR containing 21 CpG sites and average methylation ratio in each CpG site; J H19 mRNA expression; K let-7b expression. Mean ± S.E.M., n = 6 for mRNA detection and n = 3 for BSP. *p < 0.05, **p < 0.01 vs. control. DEX, dexamethasone; StAR, steroidogenic acute regulatory protein; GR, glucocorticoid receptor; CTCF, CCCTC binding factor; Dnmt3a/3b, DNA methyltransferase 3a/3b

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Cell Communication and Signaling

ISSN: 1478-811X