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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Transgenerational inheritance of adrenal steroidogenesis inhibition induced by prenatal dexamethasone exposure and its intrauterine mechanism

Fig. 2

Effects of PDE on bodyweights, adrenal steroidogenesis and related H19/let-7c axis in female fetal rats. A bodyweights; B IUGR rate; C serum CORT concentration; D StAR mRNA expression; E F StAR protein expression (immunohistochemistry staining with brown, × 400); G GR mRNA expression; H CTCF mRNA expression; I-J CTCF protein expression (immunohistochemistry staining with brown, × 400); K Dnmt3a/3b mRNA expression; L M methylation status of individual DNA strands of H19 DMR containing 10 CpG sites and average methylation ratio in each CpG site; N H19 mRNA expression; O let-7c expression. Mean ± S.E.M., n = 10 for mRNA detection, n = 3 for immunohistochemistry detection, n = 6 for let-7c detection. *p < 0.05, **p < 0.01 vs. control. PDE, prenatal dexamethasone exposure; IUGR: intrauterine growth retardation; CORT, corticosterone; StAR, steroidogenic acute regulatory protein; GR, glucocorticoid receptor; CTCF, CCCTC binding factor; Dnmt3a/3b, DNA methyltransferase 3a/3b

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Cell Communication and Signaling

ISSN: 1478-811X